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c Data are absolute differences between estimated mean changes unless stated otherwise

doi: 10.1056/NEJMoa065213

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They are also present in various brain regions, including areas involved in mood regulation, reward processing, and emotional behaviour

Chemical structures of lipoic acid and lipoyllysine residue The figure illustrates the chemical structures of lipoic acid in its oxidized and reduced forms, its two enantiomers ( R - and S -lipoic acid), and its covalent attachment to a lysine residue of the E2 component of the -ketoacid dehydrogenase complex (and the H protein of the glycine cleavage system), forming a lipoyllysine moiety