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Once the needle is fully inserted, inject the medication slowly and steadily

6 , 7 GLP1 RAs have been available as injectable formulations since exenatide received FDA approval in 2005 and as oral formulations since semaglutide was approved in 2019, 8 trials have demonstrated significant weight and HbA1c reduction benefits of GLP1 RA compared with standard of care in patients with type 2 diabetes at high cardiovascular risk

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These achieve substantially greater LDL reductions than the modest 17% decreases observed with GLP-1 receptor agonists