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In other words, this isnt just a healthcare story
Preclinical and clinical studies have demonstrated that GLP-1 receptors expressed in myocardial and vascular endothelium tissue play a fundamental role in the cardioprotective effect of GLP-1 RAs, lowering the risk of major cardiovascular events, heart failure, and kidney complications in adults with and without diabetes [4]
GLP-1 medicines act on hormone pathways involved in appetite, fullness, food intake and glucose regulation
If you have an existing thyroid condition, it is sensible to recheck your TSH and Free T4 levels 6 to 8 weeks after starting treatment or after losing a significant amount of weight (usually 510% of your body mass)
The cardiovascular and renal benefits of GLP-1 drugs are real and now well documented in outcome trials, but the receptor biology behind them is more indirect than it first appears
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