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Luciferase assay The luciferase refolding assay was performed with slight modifications as previously described 103,104
showed in senescent cells widespread mitochondrial outer membrane permeabilization in part of mitochondria enhanced mtDNA leakage to the cytoplasm and subsequent activation of the cGAS-STING pathway
Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases
doi: 10.3389/fimmu.2018.02061 162 LevringT
These two conditions also involve many of the same mechanistic causes, such as oxidative stress, inflammation, and gut dysbiosis
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