semaglutide helps depression is associated with a 44% decreased risk of and a 38% decreased risk of anxiety GLP-1 drugs linked to less

The SURPASS 2 trial was a head-to-head comparison with one of the most effective GLP-1 analogues, semaglutide, in patients only on metformin

Given the lack of liver GLP-1R expression (136), the potential mechanism of actions of GLP-1R agonists in NASH may be related to the indirect beneficial effects on body weight, IR and reduction in metabolic dysfunction, lipotoxic effects and inflammation (137)

Stem cell options vary considerably for what targets and delivery route should be used (intravascular, intrathecal, epidural, intranasal (olfactory/sphenopalatine ganglion), intraventricular, etc.), but we are on the cutting edge to optimize these therapies and publish significant research on this work in the future

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