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Some scientists hypothesize it could: Work synergistically with GLP-1 and GLP-2 Have unique metabolic or gut health effects Play a role in signaling pathways we dont yet understand For now, GLP-3 remains largely in the realm of basic research rather than practical therapeutic application
GLP-1 is also synthesized in neurons expressing preproglucagon in the nucleus tractus solitarius of the brainstem
Benefits and harms of drug treatment for type 2 diabetes: Systematic review and network meta-analysis of randomised controlled trials
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Furthermore, targeted knockdown of GLP-1 Rs in the medial habenula (MHb) or pharmacological antagonism in the interpeduncular nucleus (IPN) increases nicotine consumption and reinstates preference for nicotine-paired environments (Tuesta et al., 2017)
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