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Thus, tryptophan may be important to regulate the balance between the vitamin niacinamide, 5-HT, and melatonin because the functions of these metabolites are different (Heitkemper et al., 2016)

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In the colon, TAS1Rs have been localized in Paneth cell secretory granules, coexpressing with a-transducin, indicating a chemosensory role (60)