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Importantly, these self-reacting copper and sulfur redoxomes also interact with each other through the prominent chelation of Cu(I) by thiols of either the antioxidant copper chaperone protein Atox1 or GSH [63, 142, 160,161,162]

In fibroblast cultures, GHK-Cu has been shown to increase proliferation and upregulate markers of regenerative potential, such as integrins and p63, indicative of enhanced stemness and reparative capacity (Pickart and Margolina 2018

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In an open uncontrolled trial in 20 men with idiopathic infertility and a low testosterone-to-estrogen ratio, three months of treatment with letrozole resulted in improved sperm motility and morphology, reduced sperm DNA fragmentation, increased testosterone-to-estrogen ratio, and four spontaneous pregnancies