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*Correspondence: Yiting Zhou, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The original Diabetology Axcess formulation (chenodeoxycholate and propyl gallate in a 2:1 ratio wt:wt) has been applied in dogs, using a GLP-1 RA which has been modified to resist not only DPP4 attack, but also breakdown by intestinal proteases ( The work reported by others in dogs, as well as our own results reported here in pigs and rats, show that the Axcess formulation is able to deliver GLP-1 receptor agonists in effective amounts, even at low doses, to the intestinal mucosa

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