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In monotherapy, the most promising results were observed with the administration of 40 M fisetin, leading to a reduction in the viability of cancer cells to approximately 50% compared to the control group and the induction of apoptosis in about 20% of the cells [139]

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Enzymes require water to shed dead cells Dead cells remain attached to the surface when turnover slows

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Liposomes are generally considered stable when the zeta potential exceeds + 30 mV or is less than 30 mV, as a strong surface charge helps prevents aggregation 34,35