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Tailored Benefits for Seniors As we age, our bodies become less efficient at absorbing vitamin B12 from food due to decreased stomach acid production
This is legal and common in medicine but it should always be a deliberate clinical decision backed by evidence, not a shortcut around proper evaluation
Interestingly, in healthy men, low dietary Se intake (13 g/day for ~100 days) decreased serum, erythrocyte, and seminal plasma (but not sperm) Se concentrations, without influencing serum androgen, LH, and FSH concentrations, and decreased concentration and total number of sperm, increased the proportion of tailless sperm, but decreased the proportion of headless sperm (185)
Potential for harm due to high doses, especially in susceptible populations such as children and the elderly, also needs to be considered
Food and Drug Administration emphasizes bodycomposition monitoring and functional outcomes, reflecting the fields maturation from how much weight is lost? to what else is improving? Competitive dynamics and reimbursement pressures are already influencing trial feasibility, while treatment shortages, manufacturing scale-up and off-label demand have impacted trial operations and site engagement globally
