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The in-use period must be supported by: preservative efficacy data, microbial limits testing, and device performance data across the full container life

Archived from the original on 2008-05-27

However, the microbiome-modulating effects of antibiotics are inherently nonspecific and carry substantial risks, including severe depletion of microbial diversity, expansion of opportunistic pathogens (e.g., Clostridioides difficile ), and exacerbation of antimicrobial resistance (AMR) 175