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Clinical studies, such as the STEP trials, have shown that adults using semaglutide GLP-1 at the recommended dose (2.4 mg weekly) can lose an average of about 15% of their initial body weight over 68 weeks when combined with healthy lifestyle changes

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The broader GLP-1 class literature -- and the Phase 2 retatrutide data specifically -- documents that weight regain is common after discontinuation

11-15 Treatment of obstructive sleep apnoea Weight management Weight management continues to be a priority in the current OSA management guidelines, aiming to reduce disease severity and improve long-term health outcomes