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Celastrol specifically targets the later stages of fat cell development, decreasing fat accumulation by downregulating genes involved in fat cell formation, thus highlighting its potential as a pharmacological strategy in obesity management [26, 49]

Studies have shown that patients with fibromyalgia have high counts of pro-inflammatory cytokines (immune cells), which cause sustained inflammation

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6 Mediterranean-style eating pattern The SMILES trial diet emphasised vegetables, fruits, complex carbohydrates, legumes, nuts, olive oil, and moderate amounts of fish

Rodriguez-Valadez JM, Tahsin M, Fleischmann KE, et al