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Furthermore, at the doses of CTSs used in experiments on mice (about 0.56 mg/kg), the maximum concentration in the blood lies in the micromolar and submicromolar range, which is acceptable for rodents due to the presence of CTS-resistant 1-subunit yet lethal to other mammals, including humans, for which only nanomolar concentrations are acceptable

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The plot incorporates p-value thresholds for different levels of statistical significance ( p = 0.01, p = 0.05, and p = 0.1), which further enhances the interpretation of the results