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ROS also induce calcium dysregulation, activating calpains and caspase-3 to accelerate cytoskeletal breakdown ( Mitochondrial dysfunction is central to chronic muscle loss, with supraspinatus fibers exhibiting reduced membrane potential, impaired ATP production, and increased ROS levels following RCTs (Yazdani et al., 2022)

In contrast, intramuscular injections offer a more controlled and direct delivery method, typically leading to better outcomes

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In parallel, water loss of the skin (trans-epithelial water loss) during the hot summer season was reduced by 14% with Pycnogenol supplementation for 3 months and only by 5% with the placebo