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Given its essential role in the detoxification of lipid hydroperoxides, and its overexpression in most of myeloid malignancies, GPX4 inhibition has emerged as a promising therapeutic strategy to specifically trigger ferroptosis and eradicate myeloid leukemia cells

Some patients benefit from weekly or monthly injections

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doi: 10.1210/en.2012-1385 87 YangKZengLBaoTLongZJinB