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Neurofibromatosis type 1 is characterized primarily by caf-au-lait pigmentation, multiple neurofibromas, optic glioma, iris Lisch nodules (pigmented hamartomas of the iris), central nervous system tumors, and bone malformations

The vast number of preclinical studies on NAD + modulation via precursors or modulators of NADase enzymes has established a tight functional relationship between NAD + metabolism and mitochondrial homeostasis

Additionally, PRDX6 acts as a selenium-binding protein that promotes efficient intracellular selenium utilization, thereby sustaining GPX4 expression and activity and indirectly enhancing resistance to ferroptosis (Ito et al., 2024)

Prediction and Diagnosis of Interval Metastasis After Neoadjuvant Chemoradiotherapy For Oesophageal Cancer Using 18 F-FDG PET/CT