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Furthermore, HIF-2 represses the transcription of carnitine palmitoyltransferase 1A (CPT1A), which is responsible for mitochondrial -oxidation by transporting fatty acids and results in lipid deposition 78

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Retatrutides phase 2 data included favorable movement in lipid markers, including reductions in non-HDL cholesterol and triglycerides, alongside its striking effect on liver fat