endogenous glp 1 production Efficacy and safety of incretin co-agonists: Transformative advances in cardiometabolic healthcare Glucagon-like Peptide 1, Glucose-Dependent Insulinotropic

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Animal studies show that DPP-4 inhibition does not improve glucose homeostasis in mice with genetic deletion of GLP-1 and GIP receptors, highlighting the critical role of GLP-1 in the mechanism of action of DPP-4 inhibitors (46)