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Sugar-free options with sodium (300-500 mg per serving), potassium (100-200 mg), and magnesium (50-100 mg) are ideal

Each site has slightly different absorption characteristics

This distinction matters enormously when considering whether rotation between them is safe, effective, or even practical

As dozens of novel agents currently under study seek new indications, the question arises of whether the traditional practice of two confirmatory trials for every indication expansion remains justified, especially when database study emulations that benchmark against previously conducted, closely related reference trials have yielded aligned results 33,34

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