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In clinical trials with semaglutide injection for type 2 diabetes mellitus (T2DM), 32 (1%) of patients receiving semaglutide tested positive for anti-semaglutide antibodies

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Kumar M, Ahmad A, Rawat P, Khan MF, Rasheed N, Gupta P, Sathiamoorthy B, Bhatia G, Palit G, Maurya R

This mutation also results in a CPT1A protein that is less sensitive for the inhibitory effect of malonyl-CoA on CPT1A under fed conditions, resulting in a 34 times higher activity of CPT1A compared to wild type [91,92,93]