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This modification enhances NNTs affinity for its substrate NADP+, promoting NADPH synthesis, maintaining ironsulfur cluster homeostasis, lowering intracellular ferrous iron levels and lipid peroxidation, and thereby protecting tumor cells from ferroptosis (118)

Expression profiles of GPX and APX genes in model organism Arabidopsis indicated that stress factors, actively growing tissues, even normal physiological, and metabolic changes could induce the expression of APX/GPX genes