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Cell Rep 31(13):107833 Reimann F et al (2008) Glucose sensing in L cells: a primary cell study

In our study, criteria anchored to diabetes-related thresholds appeared to reinforce the perception that obesity alone is not a legitimate reason for treatment, potentially contributing to ongoing stigma around pharmacological treatment for weight management. The Stigma Around Help That question of who qualifies for treatment also shaped another major theme in the interviews: stigma

The study did not detect superiority of combination therapy over optimized monotherapy in terms of weight loss percentage

This involves complex cellular signaling pathways that ultimately lead to increased incretin production or enhanced receptor sensitivity

Furthermore, GPER enhances insulin responsiveness in adipose tissue, suppresses hepatic glucose production, and reduces blood glucose levels, further augmenting insulin sensitivity [4, 31]