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People with osteoarthritic knees and chronic joint inflammation have reported this as a reason for seeking the peptide

doi: 10.1016/j.nutres.2015.10.003.

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By blocking TREK-1, PE-22-28: Increases neuronal excitability : Reduces potassium efflux, depolarizing neurons toward firing threshold Enhances serotonergic transmission : TREK-1 is expressed on serotonergic neurons in the dorsal raphe nucleus

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