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Elevated ferrous ions and iron homeostasis imbalances can further increase ROS through the Fenton reaction, also contributing to ferroptosis

(2014) published foundational work demonstrating that NNMT expression in adipose tissue correlates with metabolic parameters in preclinical models

It is involved in reducing reactive oxygen species and reactive nitrogen species, which are compounds that increase during times of infection and stress

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Likewise, disulfidoptosis occurs due to SLC7A11 overexpression leading to excessive cystine uptake and depletion of NADPH, resulting in aberrant actin disulfide bonding, cytoskeletal disruption, and cell death, especially during glucose deprivation (145)