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The risk is intermediate-high for those with signs of right ventricular dysfunction or elevation of cardiac biomarkers

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Diabetes Care 44(10):24382444 Davies M, Faerch L, Jeppesen OK et al (2021) Semaglutide 2.4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial

Abbreviations 3D: Three-dimensional DARPin: Designed ankyrin repeat protein ECD: Extracellular domain GLP-1: Glucagon like peptide-1 GR: Gyration radius HSA: Human serum albumin MD: Molecular dynamics RMSD: Root mean square deviation RMSF: Root mean square fluctuation SASA: Solvent-accessible surface area T2DM: Type 2 diabetes mellitus References Piero, M., Nzaro, G