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In addition, the levels of these microbial metabolites are associated with the relative abundance of proinflammatory gut bacteria, which is consistent with an interaction between gut dysbiosis and systemic inflammation in PD [247]

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Studies have shown that topical zinc application can enhance wound repair, as demonstrated in porcine skin wound models where zinc accelerated re-epithelization [542] and increased keratinocyte migration, contributing to epidermal re-epithelization [543]