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However, a small percentage of patients discontinue treatment specifically due to persistent or severe gastrointestinal side effects

For decades, conventional dieting tried to override this system through restriction alone

Importantly, FOXO4-DRI showed no significant toxicity towards normal TM3 Leydig cells, demonstrating its selective action against senescent cells

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[4] However: The study did not measure hair loss directly It was conducted in men It has not been widely replicated Currently, evidence is insufficient to establish a link between creatine consumption and hair loss in women