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Statements Acknowledgments This work was supported by grants from Federico II University of Naples (Italy)

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These conditions include aging and age-associated chronic muscle conditions such as cachexia 248 , sarcopenia 124,249,250 , inclusion body myositis (IBM) 114,251,252 , and neuromuscular diseases like Duchennes muscular dystrophy (DMD) 253,254

The body must adjust to new weight distributions, causing pain, especially in weight-bearing joints like the knees, hips, and lower back