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However, this increase in BUN is also affected by other factors: the concomitant loss of HS at least in part explains the increase in BUN and fully explains the CLP-induced decrease in glomerular filtration rate (GFR) (98)

Khokhar, A

In a study, the administration of flavonoids was found to be inhibiting BCRP and subsequently, improving multi-drug resistance of BCRP substrates that was induced by it ( Gymnema sylvestre may improve the activity of BCRP substrates methotrexate, daunorubicin, topotecan, epirubicin, flavopiridol, and so on by increasing systemic availability and absorption (Mao, 2005)

4 When considering only NF1-associated, radiation-exposed, and sporadic malignant peripheral nerve sheath tumors, previous studies showed complete loss of H3K27 trimethylation in variable proportions: 29% (12/42), 5 34% (55/162), 10 56% (30/54), 8 57% (51/90), 6 68% (17/25), 9 73% (45/62), 4 and 75% (47/63)