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It is noteworthy that in the present study we used OA, a selective agonist of the TGR5 receptor, rather than native bile salts, to examine the regulation of PYY and GLP-1 release (Sato et al., 50 for TGR5 ligand stimulated cAMP formation and PI hydrolysis is close to the luminal bile acids concentrations and suggests that under physiological conditions it is likely that L cells would be activated by postprandial bile acids and induce GLP-1 and PYY release

individuals with Wilson's disease or those who are pregnant should seek medical advice before use

PMID: 38936270 Research Square Preprint2021 Jan

And also theres a direct effect on the cells, the chondrocyte