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Vitamin E, a fat-soluble Vitamin, is one of the main antioxidants and also inhibits ferroptosis by inhibiting the production of lipid peroxides [190]
Similar to vitamin C, vitamin E also appears to affect every aspect of the neurotoxic triad ( in vitro data which suggests that vitamin E may be able to reduce activity of the ionotropic AMPA, kainate, and NMDA glutamate receptors, in addition to protecting mitochondrial membrane potential through its antioxidant function ( in vitro and in vivo evidence that vitamin E can reduce neuroinflammatory responses mediated by microglial cells (
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