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When to Seek Medical Advice About Leg Cramps Whilst occasional, mild leg cramps during GLP-1 therapy may not require immediate medical attention, certain features warrant prompt evaluation by a healthcare professional

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Myokines, for example, secreted by skeletal muscle cells during exercise such as -aminoisobutyric acid, can impair adipogenesis via activating AMPK signaling pathway and reducing levels of proinflammatory cytokines such as TNF- [81]

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