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The compound's development represents years of medicinal chemistry optimization, resulting in a 10-fold improvement in potency over parent compounds while maintaining excellent safety margins in preclinical studies

With the unavoidable exception of DBD (deceased), all authors edited, reviewed and approved the final version of the manuscript

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In catalase and peroxidase, analysis of the crystal structure indicates strongly that amino-acid side chains are situated to aid in the cleavage by stabilizing a charge-separated transition state (Figure 5.14)

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