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Statins inhibit the HMGCR (rate-limiting enzyme) activity in early stages of mevalonate pathway and then indirectly affect a number of intermediate products, including non-sterol isoprenoids (coenzyme Q10, dolichol etc.), which can result in impaired functions of body organs

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Chronic supplementation with a mitochondrial antioxidant (MitoQ) improves vascular function in healthy older adults

This systemic mechanism is part of why TB-500 is sometimes considered for injuries that involve more diffuse tissue involvement or chronic, widespread inflammation rather than a single discrete injury site

Cell 182 , 357371.e313 (2020)