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The differential diagnosis of amelanotic melanoma includes poorly differentiated carcinoma and lymphoma [13]

This process is particularly pronounced when glutathione (GSH) is depleted or glutathione peroxidase 4 (GPX4), a key enzyme that prevents lipid oxidation, is inhibited [39]

Compounds 102, 103 and 105 were prepared as 5 M solutions and compound 104 and control compound 1 were prepared in 3 M solutions

Glutathione S-conjugates are usually sequestered by distinct ABC transporters from the cytosol into the vacuole for degradation, although breakdown of glutathione, oxidized glutathione and glutathione S-conjugates also happens outside the vacuole 56

2006;290:G293-300