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Safer options include medically supervised GLP-1 therapy, nutritional counseling, cognitive behavioral therapy (CBT), dialectical behavior therapy (DBT), and holistic approaches like mindfulness-based stress reduction

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The addition of the amino acid, taurine, is there to support the bodys own conversion to more water-soluble and less toxic bile salts

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In HG-induced HK-2 and HFD/STZ-induced C57BL/6 mouse models, melatonin accelerates the movement of PINK1 and Parkin to mitochondria, activates mitophagy, reduces oxidative stress, and inhibits inflammation, thus exerting a protective effect in DKD [146]