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It also comprises key residues that facilitate the GSH-based nucleophilic attack on the electrophilic substrate, leading to the formation of a thioether bond and the subsequent detoxification of the substrate

Data availability The RNA-seq data generated in this study has been deposited in the Gene Expression Omnibus (GEO) database at NCBI under accession code GSE249592

The Km value for CAT is within the millimolar range, which may be a far higher concentration of H 2 O 2 within the cell than physiological, implying its role predominantly under stress conditions (ern et al., 2018)

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Finally, VB and VPP inhibit A aggregation, complementing the metal ion-binding mechanism, through their direct action against A