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Specifically, time-to-on, or a latency from the treatment intake to the patient turning to on-state has been recognized as a major contributor to total daily off-time [11], and SC apomorphine treatment has been shown to rapidly and significantly reduce time-to-on in patients with Parkinsons disease experiencing delayed onset of their morning levodopa dose [29], which is consistent with the present data

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Journal of Medicinal Chemistry, 57(8), 3161-3185