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"Hypoglycemia is a concern for people with diabetes, particularly in the initial period of dose adjustment," says Alice Cheng, Associate Professor of Endocrinology, University of Toronto, Toronto, Canada, and a primary investigator of the study

Common side effects include gastrointestinal issues such as nausea, vomiting, and diarrhea, especially when starting the treatment

Isogenic pooled clones were expanded and checked for transgene expression after 48 hours of incubation in the absence or presence of the tetracycline analog, doxycycline at 10 M

Comorbidities included hypertensive diseases (I10-I16), Type 2 diabetes mellitus (E11), chronic lower respiratory diseases (J40-J47), neoplasms (C00-D49), psychoactive substance use (F10-F19), ischemic heart diseases (I20-I25), chronic kidney disease (N18), and cerebrovascular diseases (I60-I69)

Dose: The starting dose of Saxenda is 0.6 mg daily and titrates up to 3 mg daily