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Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes L Blonde 1, E J Klein, J Han, B Zhang, S M Mac, T H Poon, K L Taylor, M E Trautmann, D D Kim, D M Kendall Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity List of authors

Results may persist for 1 to 2 years

It shares 94% sequence homology with human GLP-1 but has been structurally modified to resist rapid enzymatic breakdown, giving it a significantly extended half-life compared to native GLP-1

doi: 10.1038/s41380-022-01792-4 68

In 2022, veterinarians classified 100 million dogs and cats as overweight or obese up from 80 million just five years prior, according to the Association for Pet Obesity Prevention