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Available at Published 10/06/2021
Biophys J , 116 (4), 670683
The limitation of that study was the small number of patients, but the authors concluded that compared with healthy neonates, the HIE group had increased melatonin, SOD, and NO concentrations, and the combination of melatonin to therapeutic hypothermia in infants with HIE can improve neurodevelopmental outcome at 6 months of age with effective effects in reducing oxidative stress in terms of NO and SOD serum level reduction
doi: 10.1080/07315724.2019.1657515 62 HoC-WChenH-HHsiehM-CChenC-CHsuS-PYipH-Tet al
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