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NAD+ restoration using pure exogenous NAD+ is often not practical due to its unstable nature and poor bioavailability to most cell types, so efforts have focused on oral supplementation with the NAD+ precursor compounds nicotinamide (NAM), nicotinamide riboside (NR), and nicotinamide mononucleotide (NMN)

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Aggregated peptide showed 58% lower intracellular accumulation after 24 hours compared to clear solutions, despite identical total peptide concentration in the culture medium

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