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10.1046/j.1365-313x.2003.01940.x 94 PapaiakovouG.PapageorgiouA.BakakosA.SinaniotisA

How to interpret the labs Routine labs do not prove improved endurance or mitochondrial function

What semaglutide does that tirzepatide doesn't (yet): established cardiovascular outcomes data from the SELECT trial (semaglutide reduced major adverse cardiovascular events by 20% in non-diabetic obese patients with prior CV disease)

TGF-1 is a cytokine that reduces the expression of PPAR- and the PPAR- coactivator-1a (PPARGC1A) with consequently reduced expression of CPT1 and of the FAO enzyme Peroxisomal acyl-coenzyme A oxidase 1 (Acox1) which catalyzes the desaturation of acyl-CoAs to 2- trans- enoyl-CoAs