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Traditionally, erythropoiesis is defined as a gradual, stepwise, hierarchical and unidirectional process that starts from hematopoietic stem cells (HSCs) residing in the bone marrow (in adults) and extramedullary sites, which are precursors for all types of blood cells [29]

With regard to duration of AEs, some AEs either diminish over time and/or readily cease upon cessation of the treatment

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