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In support of the idea that cross-protective immunity exists, recent HCoV infections were found to be associated with less severe COVID-19 upon infection with ancestral SARS-CoV-2 [103], and infection with SARS-CoV-2 of any variant was also associated with a reduced incidence of subsequent HCoV infection

doi:10.1067/mpd.2001.112160

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Other genes, including IL-7 and IL-2 receptor alpha HLA-C554 and HLA-DRB1*11, have protective properties [4]

Early assessment is important as ED can indicate underlying cardiovascular disease, diabetes, or hormonal imbalances