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Animal studies have demonstrated that combination therapies involving GLP-1 receptor agonists and agents targeting lipid metabolism pathways produce marked reductions in liver fat content, downregulate lipogenic enzymes, and upregulate proteins involved in lipid oxidation (41)

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WormBook Iyer LM, Nagarajan S, Woelfer M, Schoger E, Khadjeh S, Zafiriou MP, Kari V, Herting J, Pang ST, Weber T et al (2018) A context-specific cardiac beta-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart

Starting too high is the single most common mistake, and it leads to unnecessary gastrointestinal distress that could have been avoided with proper titration