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Some patients notice reduced cravings or less interest in food during this phase, but actual weight change is usually minimal at this stage

Oral semaglutide relies on the SNAC absorption enhancer, achieves only about 1% bioavailability, and must be taken fasting with no more than about 120 mL of water, followed by a 30-minute wait before eating or other medicines

One more factor to consider is hydration and electrolyte balance