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This approval is an important milestone, giving doctors and patients a new option for people at risk of MASH while also helping to address obesity and related heart and metabolic diseases.

Starting weight and metabolic health People with higher starting weights often lose more absolute weight in the early weeks, partly because their higher caloric needs create a larger deficit when appetite decreases

These sensations are most common in the first few weeks of treatment or after a dose increase and often improve as the body adjusts

By activating both GLP-1 and GIP receptors, they tend to produce greater effects on weight loss and metabolic health than single GLP-1 receptor agonists.

PIO monotherapy ( = 38% vs